精品一久久_日韩成人激情_av2016天堂网_国产成年片_日日影视_精品国产观看

Job Responsibilities/崗位職責： 1.Be familiar with the application of analytical methods for ADCs, such as DAR, residual free drug, aggregation level, endotoxin, etc. 熟悉ADC質量分析的技術手段，例如DAR、游離藥物、聚集體、內毒素檢測等； 2.Responsible for the quality analysis and data interpretation of ADC and linker-payload, including SEC, HIC, RP-HPLC, CE-SDS et al. Knowledge of ADC potency evaluation methods, as ELISA, SPR or Linker-payload characterization methods, nuclear magnetic resonance (NMR), mass spectrometry (MS), inductively coupled plasma mass spectrometry (ICP-MS)，and gas chromatography (GC), et al. are preferred. 負責ADC和毒素連接子（linker-payload）的質量分析和數據解讀，包括：SEC、HIC、RP-HPLC、CE-SDS等。了解ADC的活性評價方法例如：ELISA、SPR 或者Linker-payload的表征手段核磁共振（NMR）、質譜（MS）、電感耦合等離子體質譜（ICP-MS）、氣相色譜（GC）等分析方法者優先； 3.Support quality research and analytical method development, validation, and transfer for ADC small molecule intermediates and ADC during process development, IND application, and early clinical stages. 支持ADC小分子中間體和ADC藥物在工藝開發、IND申報階段和早期臨床階段的質量研究和分析方法開發、確認與轉移； 4.ADC analysis related trouble-shooting. 解決出現的ADC分析方法的相關問題； 5.Maintain laboratory equipment and ensure compliance with safety, environmental, and quality standards. 維護實驗室設備，確保實驗操作符合安全、環境和質量標準。